Combating the negative effects of menopause with science: Ameno.
Menopause severely impacts quality of life.
Despite the fact that over 1 billion women will experience menopause by 2025, few effective treatments exist. In addition to debilitating symptoms, menopause is associated with an increased risk of numerous conditions, including osteoporosis, dementia, depression, heart disease, and Alzheimer’s Disease.
But menopause is not a biological imperative.
Ameno: a cell therapy to treat unwanted effects of menopause.
Ameno is a cell-based approach that integrates into the body’s natural signaling processes and supports hormonal balance.
Early studies have shown that our induced pluripotent stem cell (iPSC)-derived ovarian support cells (OSCs) can undergo in vitro follicle formation and dynamically secrete therapeutically-relevant levels of key hormones.
Utilizing our OSCs, we aim to develop a cell therapy that makes the onset of menopause slow and gradual, no longer an abrupt and inevitable milestone but something we can manage and modify with medical intervention.
Goals
- Integrate dynamically into the body's chemical conversation
- Respond to signals from the brain and send hormonal feedback, mimicking the HPO axis
- Tune the levels of hormones released to each individual's needs
Gameto Selected to Receive $10 Million Award from ARPA-H’s Sprint for Women’s Health
Funding will be Used to Accelerate Research for Menopause Program, Ameno