Landmark Research

The latest publications, abstracts & posters from Gameto

Publications

April 5, 2025

Translation of a human induced pluripotent stem cell-derived ovarian support cell product to a Phase 3 enabling clinical grade product for in vitro fertilization treatment

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January 23, 2025

Rapid human oogonia-like cell specification via transcription factor-directed differentiation

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October 25, 2024

Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study

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August 7, 2024

Road to in vitro maturation (IVM), from basic science to an informed clinical practice

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July 8, 2024

Clinical procedures for in vitro maturation treatment

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May 30, 2024

Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes

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May 2, 2024

Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment

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March 28, 2024

Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF) treatment

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October 10, 2023

Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation

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April 10, 2023

Improved rescue of immature oocytes obtained from conventional gonadotropin stimulation cycles via human induced pluripotent stem cell-derived ovarian support cell co-culture

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February 21, 2023

Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

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October 19, 2022

Towards reconstituting an ovary

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Abstracts & Posters

Interim Evaluation of Optimal Minimal Stimulation Regimen For Ovarian Support Cell In Vitro Maturation: A Post Market Clinical Study

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Ovarian Support Cell In Vitro Maturation Results In Superior Embryological Efficacy Over Traditional Monophasic IVM: An Interim Analysis of a Post Market Clinical Study

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Novel cell-based strategy utilizing ovarian support cells for in vitro maturation: from proof-of-concept to clinical manufacturing

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Clinical Procedures for in vitro maturation (IVM) treatment

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First case of reported positive pregnancy from novel ovarian support cell-assisted in vitro maturation of immature oocytes derived from truncated hormonal stimulation

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Ovarian support cells enhance oocyte maturation and developmental competence by recreating a complex follicle-like environment in vitro

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Ovarian support cell in vitro maturation results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study

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Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF) treatment

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Ovarian support cell-assisted in vitro maturation of immature oocytes from truncated hormonal stimulation used in donor egg cycles

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Reproducible and Scalable Differentiation of Ovarian Support Cells from a Clinical-Grade hiPSC Line to be Applied as a Novel in Vitro Maturation Strategy for Infertility Treatment

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Survey of patient side effects experienced under minimal controlled ovarian stimulation (COS) within vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF)

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Interim analysis of patients undergoing minimal stimulation with ovarian support cell in vitro maturation (OSC-IVM) treatment for infertility as part of an observational clinical study

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Characterization of the hormonal profiles during minimal stimulation protocols in normal responder women and the assessment of their pain level after oocyte retrieval

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Comparing Different Mini-Stimulations and the Retrieval Efficiency for Obtaining Immature Oocytes for In Vitro Maturation

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In vitro matured oocytes co-cultured with human induced pluripotent stem cell-derived ovarian support cells display transcriptomic quality similar to in vivo matured oocytes

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Ovarian support cells derived from human induced pluripotent stem cells allow in vitro maturation of oocytes and embryo development in a mouse model

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Human induced pluripotent stem cell-derived ovarian support cells improve the maturation rate of immature human oocytes in vitro

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Improvement in rescue in vitro maturation outcomes using co-culture with induced pluripotent stem cell-derived ovarian support cells

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An optimized approach to generate ovarian support cells from induced pluripotent stem cells: a platform to develop therapeutics for diseases of the female reproductive system

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Ovarian support cell lines differentiated from human induced pluripotent stem cells: multi-omics characterization of a platform to develop therapeutics for diseases of the female reproductive system

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Transcription factor directed differentiation of human iPSCs to oogonia-like and ovarian granulosa-like cells

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Investigation of transcription factor function via in vitro recapitulation of human oogenesis

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